Ribosome biogenesis in disease: new players and therapeutic targets

L Jiao, Y Liu, XY Yu, X Pan, Y Zhang, J Tu… - … and Targeted Therapy, 2023 - nature.com
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

Rescuing the last-line polymyxins: achievements and challenges

SC Nang, MAK Azad, T Velkov, QT Zhou, J Li - Pharmacological reviews, 2021 - ASPET
Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

Food flavonols: Nutraceuticals with complex health benefits and functionalities

D Barreca, D Trombetta, A Smeriglio… - Trends in Food Science …, 2021 - Elsevier
Background Flavonols are one of the most promising class of bioactive compounds
belonging to the broad family of the flavonoids, characterized by a unique set of features in …

Antimicrobial resistance and recent alternatives to antibiotics for the control of bacterial pathogens with an emphasis on foodborne pathogens

YA Helmy, K Taha-Abdelaziz, HAEH Hawwas, S Ghosh… - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR) is one of the most important global public health problems.
The imprudent use of antibiotics in humans and animals has resulted in the emergence of …

Host defense peptides: Dual antimicrobial and immunomodulatory action

M Drayton, JP Deisinger, KC Ludwig… - International Journal of …, 2021 - mdpi.com
The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial
infections to become a global health concern. Antimicrobial peptides (AMPs), also known as …

Molecular engineering of antimicrobial peptides: Microbial targets, peptide motifs and translation opportunities

P Cardoso, H Glossop, TG Meikle, A Aburto-Medina… - Biophysical …, 2021 - Springer
The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …

Antibiotics and bacterial resistance—a short story of an endless arms race

A Baran, A Kwiatkowska, L Potocki - International Journal of Molecular …, 2023 - mdpi.com
Despite the undisputed development of medicine, antibiotics still serve as first-choice drugs
for patients with infectious disorders. The widespread use of antibiotics results from a wide …

Oral lefamulin vs moxifloxacin for early clinical response among adults with community-acquired bacterial pneumonia: the LEAP 2 randomized clinical trial

E Alexander, L Goldberg, AF Das, GJ Moran… - Jama, 2019 - jamanetwork.com
Importance New antibacterials are needed to treat community-acquired bacterial pneumonia
(CABP) because of growing antibacterial resistance and safety concerns with standard care …

Promising role of defensins peptides as therapeutics to combat against viral infection

SS Solanki, P Singh, P Kashyap, MS Sansi… - Microbial pathogenesis, 2021 - Elsevier
Antimicrobial peptides (AMPs) are ubiquitously present small peptides, which play a critical
function in the innate immune system. The defensin class of AMPs represented an …

Antibiotic resistance and food safety: perspectives on new technologies and molecules for microbial control in the food industry

JWF Wu-Wu, C Guadamuz-Mayorga, D Oviedo-Cerdas… - Antibiotics, 2023 - mdpi.com
Antibiotic resistance (ABR) has direct and indirect repercussions on public health and
threatens to decrease the therapeutic effect of antibiotic treatments and lead to more …