The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …

Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Mitochondrial dysfunction and excessive inflammatory responses are both sufficient to
induce pathology in age-dependent neurodegenerations. However, emerging evidence …

Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

Background Glaucoma is a chronic degenerative disease for which inflammation is
considered to play a pivotal role in the pathogenesis and progression. In this study, we …

Glaucoma is one of the leading causes of irreversible blindness in the world and remains a
major public health problem. To date, incomplete knowledge of this disease's …

In clinical glaucoma, as well as in experimental models, the loss of retinal ganglion cells
occurs by apoptosis. This final event is preceded by inflammatory responses involving the …

Glaucoma is a group of optic neuropathies characterised by the degeneration of retinal
ganglion cells, resulting in damage to the optic nerve head (ONH) and loss of vision in one …

Prostaglandin (PG) receptors represent important druggable targets due to the many diverse
actions of PGs in the body. From an ocular perspective, the discovery, development, and …

Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs) and
leads to progressive vision loss. The first pathological signs can be seen at the optic nerve …