Ultrafast magic angle spinning solid-state NMR spectroscopy: Advances in methodology and applications

Y Nishiyama, G Hou, V Agarwal, Y Su… - Chemical …, 2022 - ACS Publications
Solid-state NMR spectroscopy is one of the most commonly used techniques to study the
atomic-resolution structure and dynamics of various chemical, biological, material, and …

Solid-state NMR investigations of extracellular matrixes and cell walls of algae, bacteria, fungi, and plants

N Ghassemi, A Poulhazan, F Deligey… - Chemical …, 2021 - ACS Publications
Extracellular matrixes (ECMs), such as the cell walls and biofilms, are important for
supporting cell integrity and function and regulating intercellular communication. These …

[HTML][HTML] Solid-state NMR spectroscopy in pharmaceutical sciences

M Li, W Xu, Y Su - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …

From angstroms to nanometers: measuring interatomic distances by solid-state NMR

AA Shcherbakov, J Medeiros-Silva, N Tran… - Chemical …, 2021 - ACS Publications
Internuclear distances represent one of the main structural constraints in molecular structure
determination using solid-state NMR spectroscopy, complementing chemical shifts and …

Pharmaceutical cocrystals, salts and polymorphs: Advanced characterization techniques

E Pindelska, A Sokal, W Kolodziejski - Advanced drug delivery reviews, 2017 - Elsevier
The main goal of a novel drug development is to obtain it with optimal physiochemical,
pharmaceutical and biological properties. Pharmaceutical companies and scientists modify …

Solid-state NMR dipolar and chemical shift anisotropy recoupling techniques for structural and dynamical studies in biological systems

L Liang, Y Ji, K Chen, P Gao, Z Zhao, G Hou - Chemical Reviews, 2022 - ACS Publications
With the development of NMR methodology and technology during the past decades, solid-
state NMR (ssNMR) has become a particularly important tool for investigating structure and …

Expanding the horizons for structural analysis of fully protonated protein assemblies by NMR spectroscopy at MAS frequencies above 100 kHz

J Struppe, CM Quinn, M Lu, M Wang, G Hou… - Solid state nuclear …, 2017 - Elsevier
The recent breakthroughs in NMR probe technologies resulted in the development of MAS
NMR probes with rotation frequencies exceeding 100 kHz. Herein, we explore dramatic …

Applications of NMR to membrane proteins

SJ Opella, FM Marassi - Archives of biochemistry and biophysics, 2017 - Elsevier
Membrane proteins present a challenge for structural biology. In this article, we review some
of the recent developments that advance the application of NMR to membrane proteins, with …

Molecular interactions in posaconazole amorphous solid dispersions from two-dimensional solid-state NMR spectroscopy

X Lu, C Huang, MB Lowinger, F Yang, W Xu… - Molecular …, 2019 - ACS Publications
Molecular interactions between the active pharmaceutical ingredient and polymer have
potentially substantial impacts on the physical stability of amorphous solid dispersions …

3D structure determination of amyloid fibrils using solid-state NMR spectroscopy

A Loquet, N El Mammeri, J Stanek, M Berbon… - Methods, 2018 - Elsevier
The amyloid fold is structurally characterized by a typical cross-β architecture, which is under
debate to represent an energy-favourable folding state that many globular or natively …