WNT–β-catenin signalling—a versatile player in kidney injury and repair
SJ Schunk, J Floege, D Fliser, T Speer - Nature Reviews Nephrology, 2021 - nature.com
The WNT–β-catenin system is an evolutionary conserved signalling pathway that is of
particular importance for morphogenesis and cell organization during embryogenesis. The …
particular importance for morphogenesis and cell organization during embryogenesis. The …
Osteocyte-related cytokines regulate osteoclast formation and bone resorption
H Kitaura, A Marahleh, F Ohori, T Noguchi… - International journal of …, 2020 - mdpi.com
The process of bone remodeling is the result of the regulated balance between bone cell
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …
老年骨质疏松症现状及进展.
于龙， 王亮 - Chinese Journal of Clinical Healthcare, 2022 - search.ebscohost.com
老年性骨质疏松症以骨矿含量下降, 骨微细结构破坏为病理特征. 男性峰值骨量高于女性,
出现骨丢失的年龄迟于女性, 而且雄激素水平的下降是“渐进式”, 而非“断崖式” …
出现骨丢失的年龄迟于女性, 而且雄激素水平的下降是“渐进式”, 而非“断崖式” …
The osteocyte as a signaling cell
J Delgado-Calle, T Bellido - Physiological reviews, 2022 - journals.physiology.org
Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …
Romosozumab treatment in postmenopausal women with osteoporosis
F Cosman, DB Crittenden, JD Adachi… - … England Journal of …, 2016 - Mass Medical Soc
Background Romosozumab, a monoclonal antibody that binds sclerostin, increases bone
formation and decreases bone resorption. Methods We enrolled 7180 postmenopausal …
formation and decreases bone resorption. Methods We enrolled 7180 postmenopausal …
Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts
The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …
Role and mechanism of action of sclerostin in bone
After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass
human syndromes Van Buchem disease and sclerosteosis, extensive animal …
human syndromes Van Buchem disease and sclerosteosis, extensive animal …
RANKL biology: bone metabolism, the immune system, and beyond
T Ono, M Hayashi, F Sasaki, T Nakashima - Inflammation and …, 2020 - Springer
Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/
macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because …
macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because …
The role of the wnt/β-catenin signaling pathway in formation and maintenance of bone and teeth
P Duan, LF Bonewald - The international journal of biochemistry & cell …, 2016 - Elsevier
The Wnt signaling pathway is known as one of the important molecular cascades that
regulate cell fate throughout lifespan. The Wnt signaling pathway is further separated into …
regulate cell fate throughout lifespan. The Wnt signaling pathway is further separated into …
An overview of the regulation of bone remodelling at the cellular level
OBJECTIVES: To review the current literature on the regulation of bone remodelling at the
cellular level. DESIGN AND METHODS: The cellular activities of the cells in the basic …
cellular level. DESIGN AND METHODS: The cellular activities of the cells in the basic …