Review on Alzheimer's disease: inhibition of amyloid beta and tau tangle formation

H Ashrafian, EH Zadeh, RH Khan - International journal of biological …, 2021 - Elsevier
It is reported that approximately 40 million people are suffering from dementia, globally.
Dementia is a group of symptoms that affect neurons and cause some mental disorders …

Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?

DB Kell, E Pretorius - Biochemical Journal, 2023 - portlandpress.com
It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …

Current strategies of detecting Aβ species and inhibiting Aβ aggregation: Status and prospects

J Li, W Liao, D Huang, M Ou, T Chen, X Wang… - Coordination Chemistry …, 2023 - Elsevier
Alzheimer's disease (AD) is a central neurodegenerative disorder characterized by
behavioral disturbance and progressive cognitive impairment, and it is common in pre …

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer's and Parkinson's Diseases

W Czarnik, P Fularski, A Gajewska, P Jakubowska… - Nutrients, 2024 - mdpi.com
Many researchers propose manipulating microbiota to prevent and treat related diseases.
The brain–gut axis is an object that remains the target of modern research, and it is not …

Computational studies on phylogeny and drug designing using molecular simulations for COVID-19

F Nabi, O Ahmad, YA Khan, A Nabi… - Journal of …, 2022 - Taylor & Francis
Since the first appearance of a novel coronavirus pneumonia (NCP) caused by a novel
human coronavirus, and especially after the infection started its rapid spread over the world …

Functional effects of gut microbiota-derived metabolites in Alzheimer's disease

H Choi, I Mook-Jung - Current Opinion in Neurobiology, 2023 - Elsevier
The precise causation of Alzheimer's disease (AD) is unknown, and the factors that
contribute to its etiology are highly complicated. Numerous research has been conducted to …

Amyloid Disassembly: What Can We Learn from Chaperones?

ZL Almeida, RMM Brito - Biomedicines, 2022 - mdpi.com
Protein aggregation and subsequent accumulation of insoluble amyloid fibrils with cross-β
structure is an intrinsic characteristic of amyloid diseases, ie, amyloidoses. Amyloid …

Helicobacter pylori and Alzheimer's Disease-Related Metabolic Dysfunction: Activation of TLR4/Myd88 Inflammation Pathway from p53 Perspective and a Case Study …

Z Ju, L Shen, M Zhou, J Luo, Z Yu, C Qu… - ACS Chemical …, 2022 - ACS Publications
Gut dysbiosis is observed in Alzheimer's disease (AD) and is frequently associated with AD-
induced metabolic dysfunction. However, the extent and specific underlying molecular …

Unlocking novel therapies: Cyclic peptide design for amyloidogenic targets through synergies of experiments, simulations, and machine learning

D de Raffele, IM Ilie - Chemical Communications, 2024 - pubs.rsc.org
Existing therapies for neurodegenerative diseases like Parkinson's and Alzheimer's address
only their symptoms and do not prevent disease onset. Common therapeutic agents, such as …

Liver's influence on the brain through the action of bile acids

XY Yeo, LY Tan, WR Chae, DY Lee, YA Lee… - Frontiers in …, 2023 - frontiersin.org
The liver partakes as a sensor and effector of peripheral metabolic changes and a regulator
of systemic blood and nutrient circulation. As such, abnormalities arising from liver …