▪ Abstract Secondary lymphoid organs serve as hubs for the adaptive immune system,
bringing together antigen, antigen-presenting cells, and lymphocytes. Two families of G …

Chemokines–chemotactic cytokines–are small secreted proteins that attract and activate
immune and non-immune cells in vitro and in vivo. It has been suggested that chemokines …

Infection with the human immunodeficiency virus-1 (HIV-1) can induce severe and
debilitating neurological problems that include behavioral abnormalities, motor dysfunction …

The chemoattractant stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine
receptor 4 (CXCR4) are key modulators of immune function. In the developing brain, SDF-1 …

Myocardial infarction is associated with persistent muscle damage, scar formation and
depressed cardiac performance. Recent studies have demonstrated the clinical significance …

The chemokine CXCL12/stromal cell-derived factor 1 alpha has first been described in the
immune system where it functions include chemotaxis for lymphocytes and macrophages …

Stromal Cell-derived factor 1 (SDF-1) is a CXC chemokine that binds to the CXCR4 receptor.
Recent publication indicates that the SDF-1/CXCR4 signaling pathway plays a pivotal role …

Stromal cell-derived factor-1 is a chemoattractant produced by bone marrow stromal cell
lines. It is recognized as a critical factor in the immune and central nervous systems (CNSs) …

Chemokines were recognized originally for their ability to dictate the migration and activation
of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell …

During the development of the nervous system, populations of progenitor cells that
eventually become neurons and glia face the complex task of finding their way from their …