Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …

Mitochondria sense both biochemical and energetic input in addition to communicating
signals regarding the energetic state of the cell. Increasingly, these signaling organelles are …

Background: Without adequate treatment, pathological cardiac hypertrophy induced by
sustained pressure overload eventually leads to heart failure. WWP1 (WW domain …

Cardiac hypertrophy, a stereotypic cardiac response to increased workload, ultimately
progresses to severe contractile dysfunction and uncompensated heart failure without …

Aims/hypothesis Diabetic cardiomyopathy, characterised by increased oxidative damage
and mitochondrial dysfunction, contributes to the increased risk of heart failure in individuals …

M6A modification is an RNA-important processing event mediated by methyltransferases
METTL3 and METTL14 and the demethylases. M6A dynamic changes after myocardial …

Microtubules, a highly dynamic cytoskeleton, participate in many cellular activities including
mechanical support, organelles interactions, and intracellular trafficking. Microtubule …

Mitochondria serve as an energy plant and participate in a variety of signaling pathways to
regulate cellular metabolism, survival and immunity. Mitochondrial dysfunction, in particular …

Mitochondria are organelles present in most eukaryotic cells, where they play major and
multifaceted roles. The classical notion of the main mitochondrial function as the …