Adipokines: new potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases

L Recinella, G Orlando, C Ferrante… - Frontiers in …, 2020 - frontiersin.org
Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease

JJ Fuster, N Ouchi, N Gokce, K Walsh - Circulation research, 2016 - Am Heart Assoc
Obesity is causally linked with the development of cardiovascular disorders. Accumulating
evidence indicates that cardiovascular disease is the collateral damage of obesity-driven …

The role of adipokines in chronic inflammation

P Mancuso - ImmunoTargets and therapy, 2016 - Taylor & Francis
Adipose tissue has traditionally been defined as connective tissue that stores excess
calories in the form of triacylglycerol. However, the physiologic functions attributed to …

[HTML][HTML] The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

M Yu, K Qin, J Fan, G Zhao, P Zhao, W Zeng, C Chen… - Genes & …, 2024 - Elsevier
The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …

Metabolic adaptation in obesity and type II diabetes: myokines, adipokines and hepatokines

KJ Oh, DS Lee, WK Kim, BS Han, SC Lee… - International journal of …, 2016 - mdpi.com
Obesity and type II diabetes are characterized by insulin resistance in peripheral tissues. A
high caloric intake combined with a sedentary lifestyle is the leading cause of these …

Wnt signaling and the control of human stem cell fate

JK Van Camp, S Beckers, D Zegers… - Stem Cell Reviews and …, 2014 - Springer
Wnt signaling determines major developmental processes in the embryonic state and
regulates maintenance, self-renewal and differentiation of adult mammalian tissue stem …

Curcumin and obesity

PG Bradford - Biofactors, 2013 - Wiley Online Library
Turmeric has been long recognized for its anti‐inflammatory and health‐promoting
properties. Curcumin is one of the principal anti‐inflammatory and healthful components of …

Hypothalamic inflammation in human obesity is mediated by environmental and genetic factors

C Kreutzer, S Peters, DM Schulte, D Fangmann… - Diabetes, 2017 - Am Diabetes Assoc
Obesity is associated with hypothalamic inflammation (HI) in animal models. In the current
study, we examined the mediobasal hypothalamus (MBH) of 57 obese human subjects and …

Anti‐inflammatory cytokines and risk of type 2 diabetes

C Herder, M Carstensen… - Diabetes, Obesity and …, 2013 - Wiley Online Library
Proinflammatory processes have been investigated extensively in the development of type 2
diabetes, but our knowledge on anti‐inflammatory proteins is rather limited. This article …

Cinnamon extract combined with high-intensity endurance training alleviates metabolic syndrome via non-canonical WNT signaling

E Fayaz, A Damirchi, N Zebardast, P Babaei - Nutrition, 2019 - Elsevier
Objectives The incidence of metabolic syndrome (MetS) in menopausal women is one of the
main health care concerns. MetS clusters are related to an imbalance in pro-and anti …