Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to …

The importance of the physiological function of phosphatase and tensin homologue (PTEN)
is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3 …

PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …

Interest in the topic of tumour metabolism has waxed and waned over the past century of
cancer research. The early observations of Warburg and his contemporaries established …

The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …

The human body consists of countless cells with the possibility of excessive and
uncontrolled proliferation under certain dysregulated circumstances that could cause …

Cells from some tumors use an altered metabolic pattern compared with that of normal
differentiated adult cells in the body. Tumor cells take up much more glucose and mainly …

Reactive oxygen species (ROS) are increasingly recognised as important signalling
molecules through oxidation of protein cysteine residues. Comprehensive identification of …