Although mitochondria in brown adipose tissue and their role in non-shivering
thermogenesis have been widely studied, we have only a limited understanding of the …

Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls
developmental processes and proliferation and differentiation during the reproductive cycle …

Dynamic ensembles of macromolecules mediate essential processes in biology.
Understanding the mechanisms driving the function and molecular interactions …

Chromosomal translocations that generate in-frame oncogenic gene fusions are notable
examples of the success of targeted cancer therapies,,. We have previously described gene …

In mammals, secretin is a 27-amino acid peptide that was first studied in 1902 by Bayliss
and Starling from the extracts of the jejunal mucosa for its ability to stimulate pancreatic …

Skeletal muscle is the largest organ in the body and contributes to innumerable aspects of
organismal biology. Muscle dysfunction engenders numerous diseases, including diabetes …

Estrogen-related receptor (ERR) γ is an orphan nuclear hormone receptor that belongs to
the ERR subfamily of transcription factors. No endogenous ligand has been identified to …

The integration of biophysical data from multiple sources is critical for developing accurate
structural models of large multiprotein systems and their regulators. Mass spectrometry (MS) …

The dynamics of macromolecular conformations are critical to the action of cellular networks.
Solution X-ray scattering studies, in combination with macromolecular X-ray crystallography …

PGC-1α is a key transcription coactivator regulating energy metabolism in a tissue-specific
manner. PGC-1α expression is tightly regulated, it is a highly labile protein, and it interacts …