Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Chronic stressful life events are risk factors for developing major depression, the
pathophysiology of which is strongly linked to impairments in serotonin (5-HT) …

Major depressive disorder is a chronic, remitting syndrome involving widely distributed
circuits in the brain. Stable alterations in gene expression that contribute to structural and …

Chronic stress is a relevant disease to periodontal practice, encompassing 25%‐28% of the
US population (American Psychological Association 2015). While it is well established that …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Background Although depression is the leading cause of disability worldwide, its
pathophysiology is poorly understood. Recent evidence has suggested that sirtuins (SIRTs) …

The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …

Besides the well-known systemic factors for periodontal and peri-implant diseases,
additional co-factors, such as chronic stress and depression, may also affect disease onset …

Recent findings in epigenetics shed new light on the regulation of gene expression in the
central nervous system (CNS) during stress. The most frequently studied epigenetic …

Sodium butyrate (NaB) has exhibited neuroprotective activity. This study aimed to explore
that NaB exerts beneficial effects on chronic unpredictable mild stress (CUMS)-induced …