Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

Given their extensive role in cell signalling, GPCRs are significant drug targets; despite this,
many of these receptors have limited or no available prophylaxis. Novel drug design and …

Integral membrane proteins are among the most fascinating and important biomolecules as
they play a vital role in many biological functions. Knowledge of their atomic structures is …

Gel-free bottom-up shotgun proteomics is the principal methodological platform for the state-
of-the-art proteome research. This methodology assumes quantitative isolation of the total …

Simple Summary Membrane proteins are essential to all forms of life. Millions of membrane
proteins are found in the lipid membrane layer that surrounds cells, and in the lipid …

Accounting for nearly two-thirds of known druggable targets, membrane proteins are highly
relevant for cell physiology and pharmacology. In this regard, the structural determination of …

Integral membrane proteins are involved in a plethora of biological processes including
cellular signalling, molecular transport, and catalysis. Many of these functions are mediated …

Over the years, there have been many developments and advances in the field of integral
membrane protein research. As important pharmaceutical targets, it is paramount to …

Efflux proteins at the blood–brain barrier provide a mechanism for export of waste products
of normal metabolism from the brain and help to maintain brain homeostasis. They also …

The study of structure–function relationships of membrane proteins (MPs) has been one of
the major goals in the field of structural biology. Many Noble Prizes regarding remarkable …