Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

BC Phukan, R Roy, I Gahatraj… - Phytotherapy …, 2023 - Wiley Online Library
Leading neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease
(PD) are characterized by the impairment of memory and motor functions, respectively …

Pesticides as a risk factor for cognitive impairment: Natural substances are expected to become alternative measures to prevent and improve cognitive impairment

L Wen, X Miao, J Ding, X Tong, Y Wu, Y He… - Frontiers in …, 2023 - frontiersin.org
Pesticides are the most effective way to control diseases, insects, weeds, and fungi. The
central nervous system (CNS) is damaged by pesticide residues in various ways. By …

The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells

A Fujimaki, K Ohuchi, S Takizawa, T Murakami… - Scientific Reports, 2023 - nature.com
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of
dopaminergic neurons in the substantia nigra. The pathological hallmark of PD is the …

Extracellular vesicle–based drug delivery system boosts phytochemicals' therapeutic effect for neurodegenerative diseases

Z Zhu, L Liao, H Qiao - Acupuncture and Herbal Medicine, 2022 - journals.lww.com
Neurodegenerative diseases (NDs) are a major threat to the elderly, and efficient therapy is
rarely available. A group of phytochemicals has been shown to ameliorate NDs; however …

[HTML][HTML] Antiparkinsonian effects of polyphenols: a narrative review with a focus on the modulation of the gut-brain axis

W Zhang, X Dong, R Huang - Pharmacological Research, 2023 - Elsevier
Polyphenols, which are naturally occurring bioactive compounds in fruits and vegetables,
are emerging as potential therapeutics for neurological disorders such as Parkinson's …

Kaemperfol protects dopaminergic neurons by promoting mTOR-mediated autophagy in Parkinson's disease models

Z Liu, W Zhuang, M Cai, E Lv, Y Wang, Z Wu… - Neurochemical …, 2023 - Springer
We previously showed that kaempferol (KAE) could exert neuroprotective effects against PD.
It has been demonstrated that abnormal autophagy plays a key role in the development of …

[HTML][HTML] Kaempferol counteracts toxicity induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine in D. melanogaster: An implication of its mitoprotective activity

AO Adedara, G Wildner, JS Loreto, MM Dos Santos… - Neurotoxicology, 2023 - Elsevier
The current study aimed to investigate whether kaempferol (KMP), the major bioactive
component of green leafy vegetables, could counteract the toxicity elicited by 1-methyl-4 …

Targeting selective autophagy in CNS disorders by small-molecule compounds

Y Zheng, Z Zhou, M Liu, Z Chen - Pharmacology & Therapeutics, 2024 - Elsevier
Autophagy functions as the primary cellular mechanism for clearing unwanted intracellular
contents. Emerging evidence suggests that the selective elimination of intracellular …

Dietary flavonoids: Promising compounds for targeting α-synucleinopathy in Parkinson's disease

M Harati, Z Tayarani-Najaran, B Javadi - PharmaNutrition, 2023 - Elsevier
Background Alpha-synuclein (α-syn) aggregates contribute to neuronal damage and many
neurodegenerative disorders (NDs) which are known as α-synucleinopathies. Flavonoids …

Kaempferol counteracts bupivacaine‐induced neurotoxicity in mouse dorsal root ganglia neurons by regulating TRAF6‐dependent NF‐κB signaling

L Chen, K Zhuang - The Kaohsiung Journal of Medical …, 2023 - Wiley Online Library
Kaempferol (KA), a widely recognized anti‐oxidation and anti‐inflammation agent, has been
reported to have neuroprotective effects. This work aimed to investigate whether KA protects …