Novel biomarkers for the evaluation of aging-induced proteinopathies

K Yanar, MC Atayik, B Simsek, U Çakatay - Biogerontology, 2020 - Springer
Proteinopathies are characterized by aging related accumulation of misfolded protein
aggregates. Irreversible covalent modifications of aging proteins may significantly affect the …

[HTML][HTML] Precision Thermostability Predictions: Leveraging Machine Learning for Examining Laccases and Their Associated Genes

A Tiwari, DI Krisnawati, Widodo, TM Cheng… - International Journal of …, 2024 - mdpi.com
Laccases, multi-copper oxidases, play pivotal roles in the oxidation of a variety of substrates,
impacting numerous biological functions and industrial processes. However, their industrial …

Grb7-derived calmodulin-binding peptides inhibit proliferation, migration and invasiveness of tumor cells while they enhance attachment to the substrate

J Alcalde, M González-Muñoz, A Villalobo - Heliyon, 2020 - cell.com
The growth factor receptor bound protein 7 (Grb7) is a Ca 2+-dependent calmodulin (CaM)-
binding adaptor protein implicated, among other functions, in cell proliferation, migration and …

Cobalt(ii) cation binding by proteins

VV Khrustalev, TA Khrustaleva, VV Poboinev… - Metallomics, 2019 - academic.oup.com
Herein, a set of non-homologous proteins (238) that could bind the cobalt (ii) cations was
selected from all the available Protein Data Bank structures with Co2+ cations. The …

Microenvironment of tryptophan residues in proteins of four structural classes: applications for fluorescence and circular dichroism spectroscopy

VV Khrustalev, VV Poboinev, AN Stojarov… - European Biophysics …, 2019 - Springer
In this study we examined microenvironment of Trp residues in “dry” sets of nonhomologous
proteins that belong to four structural classes, as well as in a “wet” set. In silico experiments …

The cytoplasmic tail of influenza A/H1N1 virus hemagglutinin is β-structural

VV Khrustalev, LV Kordyukova… - Journal of …, 2022 - Taylor & Francis
Abstract Influenza A/H1N1 virus hemagglutinin (HA) is an integral type I glycoprotein that
contains a large glycosylated ectodomain, a transmembrane domain, and a cytoplasmic tail …

Sequential purification and characterization of Torpedo californica nAChR-DC supplemented with CHS for high-resolution crystallization studies

R Maldonado-Hernández, O Quesada… - Analytical …, 2020 - Elsevier
Over the past 10 years we have been developing a multi-attribute analytical platform that
allows for the preparation of milligram amounts of functional, high-pure, and stable Torpedo …

Random Coils of Proteins Situated Between a Beta Strand and an Alpha Helix Demonstrate Decreased Solvent Accessibility

VV Khrustalev - The Protein Journal, 2020 - Springer
Surface accessibility of different types of the same elements of secondary structure has been
studied in 10 non-redundant sets of proteins (total number of three-dimensional structures is …

Filamentous versus Spherical Morphology: A Case Study of the Recombinant A/WSN/33 (H1N1) Virus

LV Kordyukova, RR Mintaev… - Microscopy and …, 2020 - academic.oup.com
Influenza A virus is a serious human pathogen that assembles enveloped virions on the
plasma membrane of the host cell. The pleiomorphic morphology of influenza A virus …

Сайты связывания билирубина сывороточным альбумином человека: возможность влияния на них мутаций, вызванных радиацией

ВВ Побойнев, ВВ Хрусталев… - Известия …, 2021 - vestimed.belnauka.by
Аннотация В статье проанализированы сайты связывания билирубина сывороточным
альбумином человека с точки зрения нестабильности вторичной структуры, а также …