Catalytic enantioselective transformations provide well-established and direct access to
stereogenic synthons that are broadly distributed among active pharmaceutical ingredients …

In the area of asymmetric organocatalysis, significant effort has been dedicated during the
last decade to improve the performance of emblematic catalysts such as proline, as well as …

Chemistry in continuous-flow continues to attract attention from the community of synthetic
organic chemists due to its now well-recognized benefits including, inter alia, quick reaction …

The two-step flow asymmetric synthesis of chiral γ-nitrobutyric acids as key intermediates of
the GABA analogues baclofen, phenibut, and fluorophenibut is reported on a multigram …

In recent years, sustainable organocatalysis has become a relevant target in asymmetric
organic synthesis. Among the most successful strategies to achieve “greener” …

The increased demand for more efficient, safe, and green production in fine chemical and
pharmaceutical industry calls for the development of continuous‐flow manufacturing, and for …

Asymmetric catalysis is a rapidly evolving field in synthetic chemistry. This is due to the
growing needs of stereoselective synthetic routes to access enantiopure natural products …

The catalytic enantioselective synthesis of the chiral key intermediate of the antidepressant
(−)-paroxetine is demonstrated as a continuous flow process on multi-gram scale. The …

A novel approach is reported for the enantioselective flow synthesis of rolipram comprising a
telescoped asymmetric conjugate addition–oxidative aldehyde esterification sequence …

Isoxazol-5-ones and isoxazolidin-5-ones represent two important classes of heterocycles,
with several applications as bioactive compounds and as versatile building blocks for further …