Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Osteosarcoma is a primary malignant tumor that tends to threaten children and adolescents,
and the 5-year event-free survival rate has not improved significantly in the past three …

The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular
coupling, which is resistant to environmental perturbations. We report that primary cilia are …

With the continuous improvement of human technology, the medical field has gradually
moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool …

Background Osteoporosis is recognized as a skeletal disorder characterized by diminished
bone tissue quality and density. Regular physical exercise is widely acknowledged to …

Irisin is well-known to contribute to bone homeostasis due to its bidirectional regulation on
osteogenesis and osteoclastogenesis. However, the mechanisms of irisin involved in …

Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

Abstract Rationale: Mesenchymal stem cells (MSCs) have been the focus of many studies
because of their abilities to modulate immune responses, angiogenesis, and promote tumor …

Heterotopic ossification (HO) is pathological bone formation characterized by ossification
within muscle, tendons, or other soft tissues. However, the cells of origin and mechanisms …

Hereditary metabolic bone diseases are characterized by genetic abnormalities in skeletal
homeostasis and encompass one of the most diverse groups among rare diseases. In this …