Signalling pathways involved in sildenafil‐induced relaxation of human bladder dome smooth muscle
S Oger, D Behr‐Roussel, D Gorny… - British journal of …, 2010 - Wiley Online Library
Background and purpose: The mechanism (s) of action responsible for the beneficial effects
of phosphodiesterase 5 (PDE5) inhibitors including sildenafil on lower urinary tract …
of phosphodiesterase 5 (PDE5) inhibitors including sildenafil on lower urinary tract …
Expression and regulation of endothelin-1 and its receptors in human penile smooth muscle cells
S Granchi, GB Vannelli, L Vignozzi… - Molecular Human …, 2002 - academic.oup.com
We report for the first time that penile smooth muscle cells (SMC) not only respond to, but
also synthesize, endothelin-1 (ET-1), one of the main regulators of SMC activity …
also synthesize, endothelin-1 (ET-1), one of the main regulators of SMC activity …
Overactive bladder in the male patient: epidemiology, etiology, evaluation, and treatment
WI Jaffe, AE Te - Current Bladder Dysfunction Reports, 2006 - Springer
The urologist's approach to the diagnosis and treatment of lower urinary tract symptoms
(LUTS) in male patients has changed significantly over the past decade. Advances in the …
(LUTS) in male patients has changed significantly over the past decade. Advances in the …
Effect of sildenafil administration on penile hypoxia induced by cavernous neurotomy in the rat
L Vignozzi, A Morelli, S Filippi, GB Vannelli… - International journal of …, 2008 - nature.com
Hypoxia is a normal, physiological condition in penile tissue, which is interrupted by
reoxygenation associated to sleep-related erections. We previously described in the rat that …
reoxygenation associated to sleep-related erections. We previously described in the rat that …
Excitatory purinergic and cholinergic expression changed in a partial bladder outlet obstruction-induced overactive bladder rat model
J Huang, H Li, Y Zhang, J Liu, H Cao, Y Long - Scientific Reports, 2023 - nature.com
Overactive bladder (OAB) is a common, long-term symptom complex with a high prevalence
in women worldwide. OAB has caused a social burden, and effective treatments are urgently …
in women worldwide. OAB has caused a social burden, and effective treatments are urgently …
Activation of the ET‐1/ETA pathway contributes to erectile dysfunction associated with mineralocorticoid hypertension
FS Carneiro, KP Nunes, FRC Giachini… - The journal of sexual …, 2008 - academic.oup.com
Introduction The cavernosal tissue is highly responsive to endothelin‐1 (ET‐1), and penile
smooth muscle cells not only respond to but also synthesize ET‐1. Aim Considering that ET …
smooth muscle cells not only respond to but also synthesize ET‐1. Aim Considering that ET …
The effect of partial outlet obstruction on prostaglandin generation in the rabbit urinary bladder
JM Masick, RM Levin, MA Hass - Prostaglandins & Other Lipid Mediators, 2001 - Elsevier
Partial outlet obstruction of the urinary bladder has been demonstrated to induce specific
dysfunctions in cellular and sub-cellular membrane structures within the bladder's smooth …
dysfunctions in cellular and sub-cellular membrane structures within the bladder's smooth …
Prostaglandin E2 induces spontaneous rhythmic activity in mouse urinary bladder independently of efferent nerves
BACKGROUND AND PURPOSE The acute effects of PGE2 on bladder smooth muscle and
nerves were examined to determine the origin of PGE2‐induced spontaneous rhythmic …
nerves were examined to determine the origin of PGE2‐induced spontaneous rhythmic …
Relaxation of phasic contractile activity of human detrusor strips by cyclic nucleotide phosphodiesterase type 4 inhibition
S Oger, D Behr-Roussel, D Gorny, P Denys, T Lebret… - European urology, 2007 - Elsevier
OBJECTIVES: Detrusor smooth muscle relaxation is mainly mediated by the cyclic
adenosine monophosphate (cAMP) pathway. Elevation of cAMP levels by …
adenosine monophosphate (cAMP) pathway. Elevation of cAMP levels by …
DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum
FS Carneiro, FRC Giachini, VV Lima… - Canadian journal of …, 2008 - cdnsciencepub.com
The penis is kept in the flaccid state mainly via a tonic activity of norepinephrine and
endothelins (ETs). ET-1 is important in salt-sensitive forms of hypertension. We …
endothelins (ETs). ET-1 is important in salt-sensitive forms of hypertension. We …