▪ Abstract In the mid to late 1980s, studies were published that provided the first evidence for
the existence of glutamate receptors that are not ligand-gated cation channels but are …

In 1991 a new type of G-protein-coupled receptor (GPCR) was cloned, the type 1a
metabotropic glutamate (mGlu) receptor, which, despite possessing the defining seven …

The amino acid L-glutamate is a neurotransmitter that mediates fast neuronal excitation in a
majority of synapses in the central nervous system. Glutamate stimulates both N-methyl-D …

Metabotropic glutamate (mglu) receptors are implicated in the regulation of many
physiological and pathological processes in the CNS, including synaptic plasticity, learning …

c-Jun N-terminal kinases (JNKs) typically respond strongly to stress, are implicated in brain
development, and are believed to mediate neuronal apoptosis. Surprisingly, however, JNK …

Metabotropic glutamate receptors (mGluRs) coupled to phosphoinositide hydrolysis
desensitize in response to prolonged or repeated agonist exposure, and evidence suggests …

Glutamate regulates the function of central nervous system (CNS), in part, through the cAMP
and/or IP3/DAG second messenger‐associated metabotropic glutamate receptors (mGluRs) …

We have explored whether the desensitization of metabotropic glutamate receptors
(mGluRs) coupled to phosphoinositide hydrolysis affects the role that they play in …

Previous work has suggested that activation of mGlu5 receptor augments NMDA receptor
function and thereby may constitute a rational approach addressing glutamate hypofunction …

Signaling by the metabotropic glutamate receptor 1α (mGluR1α) can lead to the
accumulation of inositol 1, 4, 5-trisphosphate (Ins P 3) and cAMP and to the modulation of …