Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …

Histone post-translational modifications (HPTMs), as one of the core mechanisms of
epigenetic regulation, are garnering increasing attention due to their close association with …

Parkinson's disease (PD) is the most common movement disorder affecting more than 4
million people worldwide. The primary motor symptoms of the disease are due to …

In 1997 a mutation in the a-synuclein (SNCA) gene was associated with familial autosomal
dominant Parkinson's disease (PD). Since then, several loci (PARK1‐15) and genes have …

Parkinson's disease (PD) is a multifactorial disease due to a complex interplay between
genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms …

Parkinson's disease (PD) is associated with degeneration of nigrostriatal neurons due to
intracytoplasmic inclusions composed predominantly of a synaptic protein called α …

Parkinson's disease (PD) is the second most common neurodegenerative disorder with an
unclear etiology and no disease-modifying treatment to date. PD is considered a …

Histone deacetylases (HDACs) are zinc-dependent deacetylases that remove acetyl groups
from lysine residues of histones or form protein complexes with other proteins for …

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Recent
studies have investigated the involvement of epigenetic modifications in PD. Histone …