The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

We review the hemodynamic, metabolic and cellular parameters affected during early
ischemia and their changes as a function of approximate cerebral blood flow (CBF) …

The BOLD contrast mechanism has a complex relationship with functional brain activity,
oxygen metabolism, and neurovascular factors. Accurate interpretation of the BOLD signal …

Introduction The brain's energy budget can be non-invasively assessed with different
imaging modalities such as functional MRI (fMRI) and PET (fPET), which are sensitive to …

Purpose To improve the accuracy of QSM plus quantitative blood oxygen level‐dependent
magnitude (QSM+ qBOLD or QQ)‐based mapping of the oxygen extraction fraction (OEF) …

Background Understanding how vascular and metabolic factors impact on cognitive function
is essential to develop efficient therapies to prevent and treat cognitive losses in older age …

Functional magnetic resonance imaging (fMRI) techniques using the blood-oxygen level-
dependent (BOLD) signal have shown great potential as clinical biomarkers of disease …

Management of deep hypothermic (DH) cardiopulmonary bypass (CPB), a critical
neuroprotective strategy, currently relies on non-invasive temperature to guide cerebral …

The accurate identification of irreversible infarction and salvageable tissue is important in
planning the treatments for acute ischemic stroke (AIS) patients. Computed tomographic …

Studying the relationship between cerebral oxygen utilization and cognitive impairment is
essential to understanding neuronal functional changes in the disease progression of …