The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …

Double-stranded RNA (dsRNA) is associated with most viral infections—it either constitutes
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …

Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem
with a high prevalence that mainly involves intervertebral disc (IVD) degeneration …

Cells are equipped with numerous sensors that recognize nucleic acids, which probably
evolved for defence against viruses. Once triggered, these sensors stimulate the production …

The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes that currently
lacks specific treatment. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon …

The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …