Emerging therapies in cancer metabolism

Y Xiao, TJ Yu, Y Xu, R Ding, YP Wang, YZ Jiang… - Cell Metabolism, 2023 - cell.com
Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

[HTML][HTML] The integrated stress response in cancer progression: a force for plasticity and resistance

CL Lines, MJ McGrath, T Dorwart, CS Conn - Frontiers in Oncology, 2023 - frontiersin.org
During their quest for growth, adaptation, and survival, cancer cells create a favorable
environment through the manipulation of normal cellular mechanisms. They increase …

Towards development of biobetter: L-asparaginase a case study

RK Tripathy, J Anakha, AH Pande - Biochimica et Biophysica Acta (BBA) …, 2024 - Elsevier
Background L-asparaginase (ASNase) has played a key role in the management of acute
lymphoblastic leukaemia (ALL). As an amidohydrolase, it catalyzes the hydrolysis of L …

The Biocatalysis in Cancer Therapy

J Liu, H Ren, T Tang, J Wang, J Fang, C Huang… - ACS …, 2023 - ACS Publications
Biocatalysis can be defined as the use of isolated enzymes or enzymes inside cells to
convert substrates into products. The term “biocatalysis” is often used in modern organic …

L-asparaginase anti-tumor activity in pancreatic cancer is dependent on its glutaminase activity and resistance is mediated by glutamine synthetase

J Blachier, A Cleret, N Guerin, C Gil, JM Fanjat… - Experimental Cell …, 2023 - Elsevier
Abstract l-Asparaginase is a cornerstone of acute lymphoblastic leukemia (ALL) therapy
since lymphoblasts lack asparagine synthetase (ASNS) and rely on extracellular asparagine …

[HTML][HTML] Back to the future: the amazing journey of the therapeutic anti-leukemia enzyme asparaginase Erwinia chrysanthemi

WH Tong, C Rizzari - Haematologica, 2023 - ncbi.nlm.nih.gov
For several decades, asparaginase has been considered world-wide as an essential
component of combination chemotherapy for the treatment of childhood acute lymphoblastic …

Biochemical characterization and detection of antitumor activity of l-asparaginase from thermophilic Geobacillus kaustophilus DSM 7263T

Fİ Özdemir, MD Orhan, ZT Atasavum, A Tülek - Protein Expression and …, 2022 - Elsevier
L-asparaginases, which are oncolytic enzymes, have been used in clinical applications for
many years. These enzymes are also important in food processing industry due to their …

Antioxidant and L-asparaginase activities of culturable endophytic fungi from ornamental Dendrobium orchids

RW Chua, KP Song, ASY Ting - Letters in Applied Microbiology, 2024 - academic.oup.com
This study reports the antioxidant potential and L-asparaginase production of culturable
fungal endophytes from Dendrobium orchids in Malaysia. Twenty-nine isolates were …

Isolation and characterization of l-asparaginase from seaweeds collected from Rameswaram coast, Southeast India

SR Sivakumar, A Annamalai, M Ramasamy… - Vegetos, 2024 - Springer
The present study evaluates the production of l-asparaginase enzyme from the seaweeds of
Ulva intestinalis L.(green), Lobophora variegata L.(brown), and Halymenia dilatata L.(red) …

Comprehensive insight into exploring the potential of microbial enzymes in cancer therapy: Progress, challenges, and opportunities: A review

FS Hassan, EM El-Fakharany, YA El-Maradny… - International Journal of …, 2024 - Elsevier
Microbial enzymes are crucial catalysts in various industries due to their versatility and
efficiency. The microbial enzymes market has recently expanded due to increased demand …