Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social
communication, and protection against harmful effects of solar radiation. Melanogenesis is …

Theca cells function in a diverse range of necessary roles during folliculogenesis; to
synthesize androgens, provide crosstalk with granulosa cells and oocytes during …

THE pacemaker activity in the mammalian gut is responsible for generating anally
propagating phasic contractions. The cellular basis for this intrinsic activity is unknown. The …

Paramutation is a heritable epigenetic modification induced in plants by cross-talk between
allelic loci. Here we report a similar modification of the mouse Kit gene in the progeny of …

The mouse Mash-7 gene, like its Drosophila homologs of the achaete-scute complex (AS-
C), encodes a transcription factor expressed in neural precursors. We created a null allele of …

Summary HNF-3/?, a member of the HNF4/fork head family of transcription factors, is
expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of …

ABSTRACT A discovery that the protooncogene encoding the receptor tyrosine kinase, c-kit,
is allelic with the Dominant white spotting (W) locus establishes that c-kit plays a functional …

HEMATOPOIESIS IS A life-long process responsible for replenishing both hematopoietic
progenitor cells and mature blood cells from a pool of pluripotent, long-term reconstituting …

The mechanisms that regulate patterning and growth of the developing cerebral cortex
remain unclear. Suggesting a role for Wnt signaling in these processes, multiple Wnt genes …

Qualitative and quantitative clonal analysis has been used to answer three basic questions
about the establishment of the germ cell lineage in the mouse. Where do primordial germ …