[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

An update on the tissue renin angiotensin system and its role in physiology and pathology

A Nehme, FA Zouein, Z Deris Zayeri… - Journal of cardiovascular …, 2019 - mdpi.com
In its classical view, the renin angiotensin system (RAS) was defined as an endocrine
system involved in blood pressure regulation and body electrolyte balance. However, the …

Expression of ACE2, soluble ACE2, angiotensin I, angiotensin II and angiotensin-(1-7) is modulated in COVID-19 patients

IO Osman, C Melenotte, P Brouqui, M Million… - Frontiers in …, 2021 - frontiersin.org
The etiological agent of COVID-19 SARS-CoV-2, is primarily a pulmonary-tropic
coronavirus. Infection of alveolar pneumocytes by SARS-CoV-2 requires virus binding to the …

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer's disease

CE Evans, JS Miners, G Piva, CL Willis, DM Heard… - Acta …, 2020 - Springer
Mid-life hypertension and cerebrovascular dysfunction are associated with increased risk of
later life dementia, including Alzheimer's disease (AD). The classical renin–angiotensin …

Angiotensin-(1–7)

RA Santos - Hypertension, 2014 - Am Heart Assoc
Santos Cardiovascular Actions of Angiotensin-(1–7) 1139 in caveolin 3 expression and a
decrease in heat shock protein 90. 28 These 2 alterations may lead to a decrease in eNOS …

Update on the angiotensin converting enzyme 2-angiotensin (1–7)-Mas receptor axis: fetal programing, sex differences, and intracellular pathways

MC Chappell, AC Marshall, EM Alzayadneh… - Frontiers in …, 2014 - frontiersin.org
The renin-angiotensin-system (RAS) constitutes an important hormonal system in the
physiological regulation of blood pressure. Indeed, dysregulation of the RAS may lead to the …

ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease

J Kuriakose, AC Montezano, RM Touyz - Clinical Science, 2021 - portlandpress.com
The two axes of the renin–angiotensin system include the classical ACE/Ang II/AT1 axis and
the counter-regulatory ACE2/Ang-(1-7)/Mas1 axis. ACE2 is a multifunctional …

Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy

LB Teixeira, LT Parreiras-e-Silva… - Scientific reports, 2017 - nature.com
The renin-angiotensin system (RAS) plays a key role in the control of vasoconstriction as
well as sodium and fluid retention mediated mainly by angiotensin (Ang) II acting at the AT1 …

Renin-angiotensin system: The underlying mechanisms and promising therapeutical target for depression and anxiety

S Gong, F Deng - Frontiers in Immunology, 2023 - frontiersin.org
Emotional disorders, including depression and anxiety, contribute considerably to morbidity
across the world. Depression is a serious condition and is projected to be the top contributor …

Deficiency of angiotensin-converting enzyme 2 causes deterioration of cognitive function

XL Wang, J Iwanami, LJ Min, K Tsukuda… - npj Aging and …, 2016 - nature.com
The classical renin–angiotensin system (RAS), known as the angiotensin (Ang)-converting
enzyme (ACE)/Ang II/Ang II type 1 (AT1) receptor axis, induces various organ damages …