Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large
family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif …

Gliomas constitute the most frequent tumors of the brain. High-grade gliomas are
characterized by a poor prognosis caused by a set of attributes making treatment difficult …

Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine gliomas (DIPGs) are
aggressive pediatric brain tumors in desperate need of a curative treatment. Oncolytic …

Metastatic progression is the main cause of mortality in breast cancer, necessitating the
determination of the molecular events driving this process for the development of new …

The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …

The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …

The growth of glioblastoma (GBM), one of the deadliest adult cancers, is fuelled by a
subpopulation of stem/progenitor cells, which are thought to be the source of resistance and …

Mutations and altered expression of deubiquitinating enzymes (DUBs) have been found
associated with many human diseases including cancers. In this study, Ubiquitin specific …

Aberrant activation of β-catenin signaling is a critical driver for tumorigenesis, but the
mechanism underlying this activation is not completely understood. In this study, we …

Glioblastoma is the most common primary brain tumor in adults with poor overall outcome
and 5-year survival of less than 5%. Treatment has not changed much in the last decade or …