Pneumococcus remains the most common cause of community-acquired pneumonia
worldwide. Streptococcus pneumoniae is well adapted to people, and is a frequent …

Here, we review the'target-centric'genomic strategy to antimicrobial discovery and share our
perspective on identification, validation and prioritization of potential antimicrobial drug …

Background In recent years there has been an increasing problem with Staphylococcus
aureus strains that are resistant to treatment with existing antibiotics. An important starting …

High-throughput analysis of genome-wide random transposon mutant libraries is a powerful
tool for (conditional) essential gene discovery. Recently, several next-generation …

Abstract Streptococcus pyogenes (Group A Streptococcus, GAS) remains a major public
health burden worldwide, infecting over 750 million people leading to over 500,000 deaths …

CodY is a nutritional regulator mainly involved in amino acid metabolism. It has been
extensively studied in Bacillus subtilis and Lactococcus lactis. We investigated the role of …

Maintenance of the intracellular homeostasis of metal ions is important for the virulence of
many bacterial pathogens. Here, we demonstrate that the czcD gene of the human pathogen …

Enterococcus faecium has become a nosocomial pathogen of major importance, causing
infections that are difficult to treat owing to its multi-drug resistance. In particular, resistance …

Streptococcus pneumoniae D39 AdcR (adhesin competence repressor) is the first metal-
sensing member of the MarR (multiple antibiotic resistance repressor) family to be …

In recent years, Moraxella catarrhalis has established its position as an important human
mucosal pathogen, no longer being regarded as just a commensal bacterium. Further …