Causal mapping of human brain function

SH Siddiqi, KP Kording, J Parvizi, MD Fox - Nature reviews …, 2022 - nature.com
Mapping human brain function is a long-standing goal of neuroscience that promises to
inform the development of new treatments for brain disorders. Early maps of human brain …

Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment

M Wada, Y Noda, Y Iwata, S Tsugawa, K Yoshida… - Molecular …, 2022 - nature.com
Antipsychotic drugs are the mainstay in the treatment of schizophrenia. However, one-third
of patients do not show adequate improvement in positive symptoms with non-clozapine …

Post-stroke deficit prediction from lesion and indirect structural and functional disconnection

A Salvalaggio, M De Filippo De Grazia, M Zorzi… - Brain, 2020 - academic.oup.com
Behavioural deficits in stroke reflect both structural damage at the site of injury, and
widespread network dysfunction caused by structural, functional, and metabolic …

Psychosis in neurodegenerative disease: differential patterns of hallucination and delusion symptoms

G Naasan, SM Shdo, EM Rodriguez, S Spina… - Brain, 2021 - academic.oup.com
Although psychosis is a defining feature of Lewy body disease, psychotic symptoms occur in
a subset of patients with every major neurodegenerative disease. Few studies, however …

Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

A Segal, L Parkes, K Aquino, SM Kia, T Wolfers… - Nature …, 2023 - nature.com
The substantial individual heterogeneity that characterizes people with mental illness is
often ignored by classical case–control research, which relies on group mean comparisons …

Lesion network mapping for symptom localization: recent developments and future directions

J Joutsa, MD Fox - Current opinion in neurology, 2022 - journals.lww.com
Lesion network mapping can be used to map lesion-induced symptoms to brain circuits
rather than single brain regions. Recent findings have provided insight into long-standing …

Large-scale lesion symptom mapping of depression identifies brain regions for risk and resilience

NT Trapp, JE Bruss, K Manzel, J Grafman, D Tranel… - Brain, 2023 - academic.oup.com
Understanding neural circuits that support mood is a central goal of affective neuroscience,
and improved understanding of the anatomy could inform more targeted interventions in …

A neural circuit for spirituality and religiosity derived from patients with brain lesions

MA Ferguson, FL Schaper, A Cohen, S Siddiqi… - Biological …, 2022 - Elsevier
Background Over 80% of the global population consider themselves religious, with even
more identifying as spiritual, but the neural substrates of spirituality and religiosity remain …

[HTML][HTML] Clinical applications of magnetic resonance imaging based functional and structural connectivity

C Wu, F Ferreira, M Fox, N Harel, J Hattangadi-Gluth… - Neuroimage, 2021 - Elsevier
Advances in computational neuroimaging techniques have expanded the armamentarium of
imaging tools available for clinical applications in clinical neuroscience. Non-invasive, in …

A seat at the (language) table: incorporating the cerebellum into frameworks for language processing

A LeBel, AM D'Mello - Current Opinion in Behavioral Sciences, 2023 - Elsevier
Highlights•The cerebellum is consistently activated for a variety of language tasks.•The
cerebellum contributes to phonological and semantic processing.•Damage to the …