Growth hormone-releasing hormone and its analogues in health and disease

R Granata, S Leone, X Zhang, I Gesmundo… - Nature Reviews …, 2024 - nature.com
Growth hormone-releasing hormone (GHRH) and its ability to stimulate the production and
release of growth hormone from the pituitary were discovered more than four decades ago …

GHRH in diabetes and metabolism

C Steenblock, SR Bornstein - Reviews in Endocrine and Metabolic …, 2024 - Springer
Despite over a century of insulin therapy and recent advances in glucose monitoring,
diabetes and its complications remain a significant burden. Current medications are not …

Characterization and regulation of the neonatal growth hormone surge

DO Gusmao, LMM de Sousa, ME de Sousa… - …, 2024 - academic.oup.com
High neonatal growth hormone (GH) secretion has been described in several species.
However, the neuroendocrine mechanisms behind this surge remain unknown. Thus, the …

Inhibiting mitochondrial inflammation through Drp1/HK1/NLRP3 pathway: A mechanism of alpinetin attenuated aging‐associated cognitive impairment

Y Chen, C Yang, M Zou, D Wang, R Sheng… - Phytotherapy …, 2023 - Wiley Online Library
Mitochondrial inflammation triggered by abnormal mitochondrial division and regulated by
the Drp1/HK1/NLRP3 pathway is correlated with the progression of aging‐associated …

Acute severe hypoglycemia alters mouse brain microvascular proteome

SSVP Sakamuri, VN Sure, L Oruganti… - Journal of Cerebral …, 2024 - journals.sagepub.com
Hypoglycemia increases the risk related to stroke and neurodegenerative diseases,
however, the underlying mechanisms are unclear. For the first time, we studied the effect of a …

Homoplantaginin alleviates high glucose‐induced vascular endothelial senescence by inhibiting mtDNA–cGAS–STING pathway via blunting DRP1–mitochondrial …

L Wang, X Zhang, X Huang, X Sha, X Li… - The FASEB …, 2024 - Wiley Online Library
Vascular endothelial senescence is a major risk factor for diabetic vascular complications.
Abnormal mitochondrial fission by dynamically related protein 1 (DRP1) accelerates …

Disturbed hippocampal histidine metabolism contributes to cognitive impairment induced by recurrent nonsevere hypoglycemia in diabetes

K Wu, W Xie, Z Chen, L Zhou, L Wang, Y Zhou… - Biochemical and …, 2023 - Elsevier
Disturbed hippocampal histidine metabolism contributes to cognitive impairment induced by
recurrent nonsevere hypoglycemia in diabetes - ScienceDirect Skip to main contentSkip to …

[PDF][PDF] Protective and risk factors of recurrent severe hypoglycemia in adults with type 1 diabetes: A cross-sectional analysis of baseline data from the PR-IAH study

N Sakane, K Kato, S Hata, E Nishimura, R Araki… - 2022 - scholar.archive.org
Background Severe hypoglycemia (SH) remains a central problem in the management of
type 1 diabetes (T1D); however, little is known about the protective and risk factors …

[HTML][HTML] Recent advances in understanding hypothalamic control of defensive responses to hypoglycaemia

EO Staricoff, ML Evans - Current Opinion in Endocrine and Metabolic …, 2022 - Elsevier
Maintenance of normal blood glucose is important for survival. In particular, brain function is
dependent on circulating glucose. In health, a series of powerful counterregulatory defences …

Ashwagandha-An Herbal Product Used as a Neuroprotective Agent

MK Joshi - 2024 - search.proquest.com
Ayurveda, one of the oldest systems of medicine, has long utilized various herbs known for
their therapeutic properties, with Ashwagandha (ASW) being among the most prominent …