Matrix metalloproteinases (MMPs) are a group of endopeptidases that play a vital role in the
restoration of damaged skin. Through mediating various cellular events such as …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Abstract Background Extracellular vesicles (EVs) and exosomes are nano-sized, membrane-
bound vesicles shed by most eukaryotic cells studied to date. EVs play key signaling roles in …

Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …

Dynamic interactions between growth factors and extracellular matrix (ECM) are integral to
wound healing. These interactions take several forms that may be categorized as direct or …

The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors that
are members of the receptor tyrosine kinase family. Both DDRs bind a number of different …

Almost all human cancers display dysregulated expression and/or function of one or more
receptor tyrosine kinases (RTKs). The strong causative association between altered RTK …

Although genomically targeted therapies have improved outcomes for patients with lung
adenocarcinoma, little is known about the genomic alterations that drive squamous cell …

Anthocyanins, present in various fruits and vegetables as natural colorant, have been well
characterized to be involved in various bioactive properties and are wildly used for their …

Collagen, the most abundant protein in animals, is a key component of extracellular
matrices. Not only do collagens provide essential structural support for connective tissues …