The regulation and preservation of distinct intracellular and extracellular solute
microenvironments is crucial for the maintenance of cellular homeostasis. In mammals, the …

The p53 tumor suppressor is a transcription factor (TF) that exerts antitumor functions
through its ability to regulate the expression of multiple genes. Within the p53 protein resides …

Conformational flexibility conferred though regions of intrinsic structural disorder allows
proteins to behave as dynamic molecules. While it is well-known that intrinsically disordered …

Studies of diverse phylogenetic lineages reveal that protein disorder increases in concert
with organismic complexity but that differences nevertheless exist among lineages. To gain …

Developments in sequencing technologies and the sequencing of an ever-increasing
number of genomes have revolutionised studies of biodiversity and organismal evolution …

Background The p53 signalling pathway, which controls cell fate, has been extensively
studied due to its prominent role in tumor development. The pathway includes the tumor …

Structured RNA regulatory motifs exist from the prebiotic stages of the RNA world to the
more complex eukaryotic systems. In cases where a functional RNA structure is within the …

B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2
family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) …

The p53 family of transcription factors plays key roles in development, genome stability,
senescence and tumor development, and p53 is the most important tumor suppressor …

The mammalian CIP/KIP family proteins are intrinsically disordered proteins (IDPs) that can
regulate various cellular processes. However, many reports have shown that IDPs generally …