Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …

Therapeutic strategies to protect the ischemic myocardium have been studied extensively.
Reperfusion is the definitive treatment for acute coronary syndromes, especially acute …

The mitochondrial permeability transition pore was originally described in the 1970's as a
Ca 2+ activated pore and has since been attributed to the pathogenesis of many diseases …

Following an acute myocardial infarction (AMI), early coronary artery reperfusion remains
the most effective means of limiting the eventual infarct size. The resultant left ventricular …

Limitation of infarct size by ischemic/pharmacological pre-and postconditioning involves
activation of a complex set of cell-signaling pathways. Multiple lines of evidence implicate …

One of the greatest examples of integrated signal transduction is revealed by examination of
effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of …

Reperfusion has the potential to introduce additional injury that is not evident at the end of
ischaemia per se, ie reperfusion injury. Reperfusion injury is expressed as endothelial and …

Despite current optimal treatment, the morbidity and mortality of coronary heart disease
(CHD), the leading cause of death worldwide, remains significant, paving the way for the …

• Introduction• Mitochondria and cell death• Mitochondrial outer membrane permeabilization
(MOMP): point of no return‐MOMP by BCL‐2 family proteins‐MOMP by permeability …

Coronary heart disease (CHD) is the leading cause of morbidity and mortality worldwide. For
a large number of patients with CHD, coronary artery bypass graft (CABG) surgery remains …