Thrombin is a multifunctional serine protease produced from prothrombin, and is a key
regulator in hemostatic and non‐hemostatic processes. It is the main effector protease in …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Common causes include gram-negative and gram-positive bacteria as …

The deleterious effects of diabetes in the heart are increasingly attributed to inflammatory
signaling through the NLRP3 (NOD, LRR and PYD domains-containing protein 3) …

Thrombin triggers activation of platelets through protease-activated receptor 1 (PAR-1) and
PAR-4. Both receptors are widely expressed and exert multiple platelet-independent …

Background Protease‐activated receptor 4 (PAR4) is expressed by a wide variety of cells,
including megakaryocytes/platelets, immune cells, cardiomyocytes, and lung epithelial cells …

Inflammation is a protective reaction of the microcirculation. However, sustained
inflammation can lead to undesired effects. Thuja occidentalis Linn has many …

Protease-activated receptor 4 (PAR4) is a G protein-coupled receptor activated by thrombin.
In the platelet, response to thrombin PAR4 contributes to the predominant procoagulant …

Background: Cardiac rupture is a major lethal complication of acute myocardial infarction
(MI). Despite significant advances in reperfusion strategies, mortality from cardiac rupture …

PAR4 is expressed by a variety of cells, including platelets, cardiac, lung and immune cells.
We investigated the contribution of PAR4 to viral infections of the heart and lung. Toll-like …

Abstract CD4+ FoxP3+ regulatory T cells (CD4+ Tregs) are known to dampen inflammation
following severe trauma. Platelets were shown to augment their posttraumatic activation in …