The utilization of recent advances in molecular and genomic technologies and progress in
pancreatic imaging techniques provided remarkable insight into genetic, environmental …

Chronic alcohol use has been linked to chronic pancreatitis for over a century, but it has not
been until the last decade that the role of alcohol in chronic pancreatitis has been elucidated …

Genetic investigations have provided unique insight into the mechanism of chronic
pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central …

Background & Aims: Gain-of-function trypsin mutations cause acute pancreatitis and chronic
pancreatitis. Loss of trypsin inhibitor function may have similar effects. We investigated the …

In the past decade, our understanding of the genetic basis, pathogenesis, and natural
history of pancreatitis has grown strikingly. In severe acute pancreatitis, intensive medical …

Objective In chronic pancreatitis (CP), alterations in several genes have so far been
described, but only small cohorts have been extensively investigated for all predisposing …

The Huntington's disease (HD) protein, huntingtin (HTT), is essential for early development.
Because suppressing the expression of mutant HTT is an important approach to treat the …

Background & Aims Acute pancreatitis (AP) is a complex disease and the leading cause of
gastrointestinal disease–related hospital admissions. Few therapeutic options exist for AP …

Azoospermia, characterized by the absence of spermatozoa in the ejaculate, is a common
cause of male infertility with a poorly characterized etiology. Exome sequencing analysis of …

BACKGROUND: No data on chronic pancreatitis in Italy are available yet. AIM: To evaluate
demographic, clinical, diagnostic and therapeutic aspects in patients suffering from chronic …