To discover anti-acetylcholinesterase agents for the treatment of Alzheimer's disease (AD), a series of novel Schiff base-coumarin hybrids was rationally designed, synthesized …
Abstract In this study, N-[3-(3-amino-1, 4-dioxo-1, 4-dihydronaphthalen-2-yl)-4-R-thiazol-2 (3H)-ylidene]-2, 6-difluorobenzamide derivatives as new 1, 4-naphthoquinone thiazole …
G Kumari, S Dhillon, P Rani, M Chahal, DK Aneja… - ACS …, 2024 - ACS Publications
Heterocyclic hybrid frameworks represent a burgeoning domain within the realms of drug discovery and medicinal chemistry, attracting considerable attention in recent years …
Inflammation is a complex set of interactions that can occur in tissues as the body's defensive response to infections, trauma, allergens, or toxic compounds. Therefore, in …
A Abdalla Ali, SA Mhamad, AH Hasan… - Journal of …, 2024 - Taylor & Francis
Acetylcholinesterase inhibitors (AChEIs) have become a significant target in the search for an efficient treatment of Alzheimer's disease. Chalcone-based compounds display a strong …
S Kumari, R Saini, A Mishra - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
This research explored novel antidiabetic drugs from natural sources using the Ayurvedic Rasayana herb Ichnocarpus frutescens through invitro enzyme assay, kinetics study, and …
I Waziri, HM Masena, TL Yusuf, LCC Coetzee… - New Journal of …, 2023 - pubs.rsc.org
An equimolar reaction of 5-chlorosalicylaldehyde and 2-bromo-4-chloroaniline yielded the Schiff base (Z)-2-((2-bromo-4-chlorophenyl) imino) methyl)-4-chlorophenol)(HL), which was …
Introduction: The rising numbers of multiple drug-resistant (MDR) pathogens and the consequent antibacterial therapy failure that resulted in severe medical conditions push to …
Antimicrobial and anticancer drugs are widely used due to increasing widespread infectious diseases caused by microorganisms such as bacterial, fungal, viral agents, or cancer cells …