In his seminal work, 1 Rolf Huisgen defined 1, 3-dipolar cycloadditions as “1, 3-Dipole, abc,
must be defined, such that atom a posseses an electron sextet, that is, an incomplete …

Conspectus Organic chemistry has undoubtedly had a profound impact on humanity. Day in
and day out, we find ourselves constantly surrounded by organic compounds …

Over the last decades, excellent computational chemistry tools have been developed.
Integrating them into a single platform with enhanced accessibility could help reaching their …

Large language models (LLMs) have shown strong performance in tasks across domains
but struggle with chemistry-related problems. These models also lack access to external …

Halogen bonding is a noncovalent interaction similar to hydrogen bonding, which is based
on electrophilic halogen substituents. Hydrogen‐bonding‐based organocatalysis is a well …

In contrast to iodine (I)‐based halogen bond donors, iodine (III)‐derived ones have only
been used as Lewis acidic organocatalysts in a handful of examples, and in all cases they …

Until recently, computational tools were mainly used to explain chemical reactions after
experimental results were obtained. With the rapid development of software and hardware …

Enantioselective synthesis with small-molecule chiral hydrogen-bond donors has emerged
as a frontier of research in the field of asymmetric catalysis. Organic chemists have …

Organic syntheses are composed of two main types of reactions: Carbon-carbon bond
formations and functional group transformations. CC bond formation is the essence of …

The term “organocatalysis” describes the acceleration of chemical reactions through the
addition of a substoichiometric quantity of an organic compound. The interest in this field has …