Is Cys (MTSL) the Best α-Amino Acid Residue to Electron Spin Labeling of Synthetically Accessible Peptide Molecules with Nitroxides?

B Biondi, VN Syryamina, G Rocchio, A Barbon… - ACS …, 2022 - ACS Publications
Electron paramagnetic resonance spectroscopy, particularly its pulse technique double
electron–electron resonance (DEER)(also termed PELDOR), is rapidly becoming an …

Structural characterization and inhibition of the interaction between ch-TOG and TACC3

J Shelford, SG Burgess, E Rostkova, MW Richards… - bioRxiv, 2024 - biorxiv.org
The mitotic spindle is a bipolar array of microtubules, radiating from the poles which each
contain a centrosome, embedded in pericentriolar material. Two proteins, ch-TOG and …

Detection of Ligand‐induced Conformational Changes in the Activation Loop of Aurora‐A Kinase by PELDOR Spectroscopy

SG Burgess, M Grazia Concilio, R Bayliss… - …, 2016 - Wiley Online Library
The structure of protein kinases has been extensively studied by protein crystallography.
Conformational movement of the kinase activation loop is thought to be crucial for regulation …

Spin labeling of surface cysteines using a bromoacrylaldehyde spin label

G Heaven, MA Hollas, L Tabernero… - Applied Magnetic …, 2021 - Springer
Structural investigations of proteins and their biological complexes are now frequently
complemented by distance constraints between spin labeled cysteines generated using …

Nitroxide Intervention in Oxidative and Free Radical Damage in Biology and Disease

SE Bottle, G Eng, P Witting, B Chami - 2021 - books.rsc.org
Free radicals, more often simply called 'radicals', are broadly recognised as being highly
reactive, extremely short-lived species. Radicals typically undergo relatively non-selective …