MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a critical role in the
pathogenesis of a variety of proliferative vascular diseases. Recently, we have found that …

Vascular injury triggers dedifferentiation and cytoskeletal remodeling of smooth muscle cells
(SMCs), culminating in vessel occlusion. Serum response factor (SRF) and its coactivator …

Vascular smooth muscle cells (VSMCs) are able to perform both contractile and synthetic
functions, which are associated with changes in morphology, proliferation, and migration …

Abstract KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a
number of gene promoters and regulating their transcription. KLF5 is expressed during …

The Kruppel-like factor 5 (KLF5) transcription factor is highly expressed in high-grade and
basal-like breast cancers. However, the mechanism by which KLF5 promotes cell migration …

Cardiovascular diseases (CVDs) are major causes of death worldwide. Identification of
promising targets for prevention and treatment of CVDs is paramount in the cardiovascular …

Disturbances in gene expression as a result of perturbed transcription or posttranscriptional
regulation is one of the main causes of cellular dysfunction that underlies different disease …

Although dysregulation of mitochondrial dynamics has been linked to cellular senescence,
which contributes to advanced age-related disorders, it is unclear how Krüppel-like factor 5 …