Bladder cancer is one of the most common malignancies in the world. Cisplatin is one of the
most potent and widely used anticancer drugs and has been employed in several …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …

Simple Summary Transcription factor NRF2 controls expression of antioxidant and
detoxification genes. Normally, the activity of NRF2 is tightly controlled in the cell, and is …

Bladder cancer (BC) is a common malignancy in males, and currently lacks ideal therapeutic
approaches. Exploring emerging therapeutic targets from the perspective of endogenous …

Atherosclerosis, a disease process characterized by lipid accumulation and inflammation, is
the main cause of coronary heart disease (CHD) and myocardial infarction (MI) …

The urothelium is a stratified epithelium composed of basal cells, one or more layers of
intermediate cells, and an upper layer of differentiated umbrella cells. Most bladder cancers …

Tyrosine kinase inhibitors represented by sorafenib are the first‐line treatment for
hepatocellular carcinoma (HCC), but the low response rate of HCC patient has become a …

The underlying molecular mechanisms of resistance to cisplatin-based systemic
chemotherapy in bladder cancer patients remain to be elucidated, while the link between …

The Hippo signaling pathway plays a key role in tumorigenesis in different cancer types. We
investigated the role of the Hippo “effector” YAP1 on the tumor immune microenvironment …

Urothelial bladder cancer (UBC) is one of the most prevalent malignancies worldwide, with
striking tumor heterogeneity. Elucidating the molecular mechanisms that can be exploited for …