Multi-target drug candidates for multifactorial Alzheimer's disease: AChE and NMDAR as molecular targets
MS Uddin, A Al Mamun, MT Kabir, GM Ashraf… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is one of the most common forms of dementia among elder
people, which is a progressive neurodegenerative disease that results from a chronic loss of …
people, which is a progressive neurodegenerative disease that results from a chronic loss of …
Mediterranean products as promising source of multi-target agents in the treatment of metabolic syndrome
Alteration of nutritional habits play an essential role on the risk of developing Metabolic
Syndrome (MetS). Several epidemiological studies have shown that assuming diets rich of …
Syndrome (MetS). Several epidemiological studies have shown that assuming diets rich of …
4-(5-Amino-pyrazol-1-yl) benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and …
In the current medical era, the single target inhibition paradigm of drug discovery has given
way to the multi-target design concept. As the most intricate pathological process …
way to the multi-target design concept. As the most intricate pathological process …
Developments with multi-target drugs for Alzheimer's disease: An overview of the current discovery approaches
JF González, AR Alcántara, AL Doadrio… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Alzheimer's disease (AD), the most common type of dementia among older
adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive …
adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive …
LigBuilder V3: A Multi-Target de novo Drug Design Approach
With the rapid development of systems-based pharmacology and poly-pharmacology,
method development for rational design of multi-target drugs has becoming urgent. In this …
method development for rational design of multi-target drugs has becoming urgent. In this …
Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities
DA Rodrigues, PSM Pinheiro… - Medicinal research …, 2020 - Wiley Online Library
Despite the applicability of histone deacetylase inhibitors (HDACis) for cancer treatment,
several works in the literature have shown that these inhibitors can be used in several other …
several works in the literature have shown that these inhibitors can be used in several other …
Machine learning, artificial intelligence, and data science breaking into drug design and neglected diseases
J Peña‐Guerrero, PA Nguewa… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Abstract Machine learning (ML) is becoming capable of transforming biomolecular
interaction description and calculation, promising an impact on molecular and drug design …
interaction description and calculation, promising an impact on molecular and drug design …
A supramolecular approach to structure-based design with a focus on synthons hierarchy in ornithine-derived ligands: Review, synthesis, experimental and in silico …
The success of innovative drugs depends on an interdisciplinary and holistic approach to
their design and development. The supramolecular architecture of living systems is …
their design and development. The supramolecular architecture of living systems is …
Therapeutic potential of phosphodiesterase inhibitors against neurodegeneration: The perspective of the medicinal chemist
Increasing human life expectancy prompts the development of novel remedies for cognitive
decline: 44 million people worldwide are affected by dementia, and this number is predicted …
decline: 44 million people worldwide are affected by dementia, and this number is predicted …
A review of the recent advances in Alzheimer's disease research and the utilization of network biology approaches for prioritizing diagnostics and therapeutics
Alzheimer's disease (AD) is a polygenic multifactorial neurodegenerative disease that, after
decades of research and development, is still without a cure. There are some symptomatic …
decades of research and development, is still without a cure. There are some symptomatic …