HIV assembly and replication proceed through the formation of morphologically distinct
immature and mature viral capsids that are organized by the Gag polyprotein (immature) …

Over the past several decades, extensive research into the Gag polyprotein, the main
structural protein of HIV-1 and all other retroviruses, has changed the way that we describe …

Exosomes are secreted, single membrane organelles of∼ 100 nm diameter. Their
biogenesis is typically thought to occur in a two-step process involving (1) outward vesicle …

During the late phase of HIV type 1 (HIV-1) replication, newly synthesized retroviral Gag
proteins are targeted to the plasma membrane of most hematopoietic cell types, where they …

Exosomes are secreted organelles that have the same topology as the cell and bud outward
(outward is defined as away from the cytoplasm) from endosome membranes or endosome …

Human immunodeficiency virus is undoubtedly the causative agent of AIDS. The
understanding of HIV-1 pathogenesis is essentiell to develop and maintain antiretroviral …

Retroviral assembly and budding is driven by the Gag polyprotein and requires the host‐
derived vacuolar protein sorting (vps) machinery. With the exception of human …

The myristoylated matrix protein (myr-MA) of HIV functions as a regulator of intracellular
localization, targeting the Gag precursor polyprotein to lipid rafts in the plasma membrane …

The major structural elements of retroviruses are contained in a single polyprotein, Gag,
which in human immunodeficiency virus type 1 (HIV‐1) comprises the MA, CA, spacer …

Exosomes are secreted cellular vesicles that can be internalized by dendritic cells (DCs),
contributing to antigen-specific naive CD4+ T-cell activation. Here, we demonstrate that …