The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …

Summary ATG9A and ATG2A are essential core members of the autophagy machinery.
ATG9A is a lipid scramblase that allows equilibration of lipids across a membrane bilayer …

The key event in macroautophagy is the de novo formation of a new organelle called the
autophagosome which when complete, will have captured bits of cytoplasm within its double …

Autophagosomes are unique organelles that form de novo as double-membrane vesicles
engulfing cytosolic material for destruction. Their biogenesis involves membrane …

Lipid transfer between organelles requires proteins that shield the hydrophobic portions of
lipids as they cross the cytoplasm. In the last decade a new structural form of lipid transfer …

Autophagy is a conserved intracellular degradation pathway that generates de novo double-
membrane autophagosomes to target a wide range of material for lysosomal degradation. In …

Autophagy is characterized by the formation of double-membrane vesicles called
autophagosomes. Autophagy-related proteins (ATGs) 2A and 9A have an essential role in …

Nonvesicular lipid transport among different membranes or membrane domains plays
crucial roles in lipid homeostasis and organelle biogenesis. However, the forces that drive …

Macroautophagy is characterized by the de novo formation of double-membrane vesicles
termed autophagosomes. The precursor structure of autophagosomes is a membrane …

The characterization of lipid binding to lipid transfer proteins (LTPs) is fundamental to
understand their molecular mechanism. However, several structures of LTPs, and notably …