Agomelatine: a potential novel approach for the treatment of memory disorder in neurodegenerative disease

Q Su, T Li, GW Liu, YL Zhang, JH Guo… - Neural Regeneration …, 2023 - journals.lww.com
Agomelatine is a selective agonist of melatonin receptor 1A/melatonin receptor 1B (MT 1/MT
2) and antagonist of 5-hydroxytryptamine 2C receptors. It is used clinically to treat major …

Vascular contributions to cognitive impairment and dementia: topical review of animal models

JB Madigan, DM Wilcock, AH Hainsworth - Stroke, 2016 - Am Heart Assoc
1954 Stroke July 2016 white matter damage. 11 ACAS mice exhibited gradual reduction of
CBF> 28 days, and multiple infarct damage in subcortical regions ipsilateral to the ameroid …

Minocycline ameliorates prenatal valproic acid induced autistic behaviour, biochemistry and blood brain barrier impairments in rats

H Kumar, B Sharma - Brain research, 2016 - Elsevier
Autism is a neurodevelopment disorder. One percent worldwide population suffers with
autism and males suffer more than females. Microglia plays an important role in …

Memantine ameliorates autistic behavior, biochemistry & blood brain barrier impairments in rats

H Kumar, B Sharma - Brain research bulletin, 2016 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, commonly characterized
by altered social behavior, communication, biochemistry and pathological conditions. One …

Benefits of agomelatine in behavioral, neurochemical and blood brain barrier alterations in prenatal valproic acid induced autism spectrum disorder

H Kumar, BM Sharma, B Sharma - Neurochemistry International, 2015 - Elsevier
Valproic acid administration during gestational period causes behavior and biochemical
deficits similar to those observed in humans with autism spectrum disorder. Although …

Neuroprotective effects of agomelatine and vinpocetine against chronic cerebral hypoperfusion induced vascular dementia

S Gupta, P Singh, B Mohan Sharma… - Current Neurovascular …, 2015 - ingentaconnect.com
Chronic cerebral hypoperfusion (CCH) has been considered as a critical cause for the
development of cognitive decline and dementia of vascular origin. Melatonin receptors have …

Melatonin ameliorates Aβ1-42-induced Alzheimer's cognitive deficits in mouse model

YH Gong, N Hua, X Zang, T Huang… - Journal of Pharmacy and …, 2018 - academic.oup.com
Objectives The objective of this study was to evaluate whether melatonin could ameliorate
cognitive function in Aβ1-42-induced mouse model and its underlying mechanisms …

Altered Blood Brain Barrier Permeability and Oxidative Stress in Cntnap2 Knockout Rat Model

I Memis, R Mittal, E Furar, I White, RS Eshraghi… - Journal of clinical …, 2022 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by three
core symptoms, specifically impaired social behavior, stereotypic/repetitive behaviors, and …

Protective effect of transient receptor potential vanilloid subtype 1 (TRPV1) modulator, against behavioral, biochemical and structural damage in experimental models …

S Jayant, BM Sharma, B Sharma - Brain research, 2016 - Elsevier
Alzheime's disease (AD) is an overwhelming neurodegenerative disorder, characterized by
synaptic dysfunction, memory loss, neuro-inflammation and neural cell death. Very few …

Neuronal changes after chronic high blood pressure in animal models and its implication for vascular dementia

G Flores, GD Flores‐Gómez… - Synapse, 2016 - Wiley Online Library
Vascular dementia is a devastating disorder not only for the patient, but also for the family
because this neurocognitive disorder breaks the patient's independence, and leads to family …