Hsp70 chaperone machineries have pivotal roles in an array of fundamental biological
processes through their facilitation of protein folding, disaggregation, and remodeling. The …

The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …

Aberrant, misfolded, and mislocalized proteins are often toxic to cells and result in many
human diseases. All proteins and their mRNA templates are subject to quality control. There …

To promote the biochemical reactions of life, cells can compartmentalize molecular
interaction partners together within separated non–membrane-bound regions. It is unknown …

Protein misfolding leads to the formation of aggregated proteins and protein inclusions,
which are associated with synaptic loss and neuronal death in neurodegenerative diseases …

Protein transport into the mammalian endoplasmic reticulum (ER) is mediated by the
heterotrimeric Sec61 channel. The signal recognition particle (SRP) and TRC systems and …

In mammalian cells, one-third of all polypeptides are transported into or across the ER
membrane via the Sec61 channel. While the Sec61 complex facilitates translocation of all …

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …

Recently, understanding of protein targeting to the endoplasmic reticulum (ER) was
expanded by the discovery of multiple pathways that function in parallel to the signal …

Proteins targeted to the secretory pathway start their intracellular journey by being
transported across biological membranes such as the endoplasmic reticulum (ER). A central …