Design of experiments (DoE) to develop and to optimize nanoparticles as drug delivery systems

MT Luiz, JSR Viegas, JP Abriata, F Viegas… - European Journal of …, 2021 - Elsevier
Nanotechnology has been widely applied to develop drug delivery systems to improve
therapeutic performance. The effectiveness of these systems is intrinsically related to their …

Chronic inflammatory diseases, anti-inflammatory agents and their delivery nanosystems

D Placha, J Jampilek - Pharmaceutics, 2021 - mdpi.com
Inflammatory diseases, whether caused by excessive stress on certain tissues/parts of the
body or arising from infections accompanying autoimmune or secondary diseases, have …

Curcumin loaded nanostructured lipid carriers for enhanced skin retained topical delivery: optimization, scale-up, in-vitro characterization and assessment of ex-vivo …

VK Rapalli, V Kaul, T Waghule, S Gorantla… - European Journal of …, 2020 - Elsevier
Nanostructured lipid carriers (NLC) have become a promising drug delivery system for
topical delivery of drugs. Delivery of lipophilic drugs with improved stability and entrapment …

[HTML][HTML] Apremilast loaded lyotropic liquid crystalline nanoparticles embedded hydrogel for improved permeation and skin retention: An effective approach for …

VK Rapalli, Y Tomar, S Sharma, A Roy… - Biomedicine & …, 2023 - Elsevier
The present work aimed to prepare and evaluate Apremilast loaded lyotropic liquid
crystalline nanoparticles (LCNPs) formulation for skin delivery to enhance the efficacy with …

Immunomodulatory nanosystems for treating inflammatory diseases

N Ahamad, A Kar, S Mehta, M Dewani, V Ravichandran… - Biomaterials, 2021 - Elsevier
Inflammatory disease (ID) is an umbrella term encompassing all illnesses involving chronic
inflammation as the central manifestation of pathogenesis. These include, inflammatory …

Recent advances in pain management based on nanoparticle technologies

S Babaie, A Taghvimi, JH Hong… - Journal of …, 2022 - Springer
Background Pain is a vital sense that indicates the risk of injury at a particular body part.
Successful control of pain is the principal aspect in medical treatment. In recent years, the …

Development and optimization of imiquimod-loaded nanostructured lipid carriers using a hybrid design of experiments approach

S Kim, S Abdella, F Abid, F Afinjuomo… - International Journal …, 2023 - Taylor & Francis
Background Imiquimod (IMQ) is an immunomodulating drug that is approved for the
treatment of superficial basal cell carcinoma, actinic keratosis, external genital warts and …

Glioblastoma multiforme targeted delivery of docetaxel using bevacizumab-modified nanostructured lipid carriers impair in vitro cell growth and in vivo tumor …

LD Di Filippo, JL Duarte, JH Azambuja… - International journal of …, 2022 - Elsevier
Glioblastoma multiforme (GBM) is the most common malignant brain cancer, characterized
by high invasiveness and poor prognosis. Docetaxel (DTX) is a chemotherapeutic drug with …

Solid lipid nanocarriers embedded hydrogel for topical delivery of apremilast: In-vitro, ex-vivo, dermatopharmacokinetic and anti-psoriatic evaluation

VK Rapalli, S Sharma, A Roy, A Alexander… - Journal of Drug Delivery …, 2021 - Elsevier
The present work aimed to develop topical solid lipid nanocarriers (SLN) loaded hydrogel of
apremilast (API) for psoriasis therapy to minimize the systemic adverse effects. The quality …

Predicting adsorption behavior and anti-inflammatory activity of naproxen interacting with pure boron nitride and boron phosphide fullerene-like cages

Y Cao, A Khan, F Ghorbani, H Mirzaei, P Singla… - Journal of Molecular …, 2021 - Elsevier
The adsorption of naproxen (NPX) on surface of the boron phosphide (BP) and boron nitride
(BN) fullerene-like cages have been studied and discussed by using density functional …