Past, present, and future of circ RNA s

IL Patop, S Wüst, S Kadener - The EMBO journal, 2019 - embopress.org
Exonic circular RNA s (circ RNA s) are covalently closed RNA molecules generated by a
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of …

Circular RNA and its mechanisms in disease: from the bench to the clinic

B Han, J Chao, H Yao - Pharmacology & therapeutics, 2018 - Elsevier
The emerging recognition of the functional roles of circular RNAs (circRNAs) has given rise
to a new perspective regarding our understanding of cellular physiology and disease …

A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation

VM Conn, V Hugouvieux, A Nayak, SA Conos… - Nature plants, 2017 - nature.com
Circular RNAs (circRNAs) are a diverse and abundant class of hyper-stable, non-canonical
RNAs that arise through a form of alternative splicing (AS) called back-splicing. These single …

[HTML][HTML] Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis

MV Pinti, GK Fink, QA Hathaway… - American Journal …, 2019 - journals.physiology.org
Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia,
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …

Circular RNAs—the road less traveled

A Guria, P Sharma, S Natesan, G Pandi - Frontiers in molecular …, 2020 - frontiersin.org
Circular RNAs are the most recent addition in the non-coding RNA family, which has started
to gain recognition after a decade of obscurity. The first couple of reports that emerged at the …

Efficient deletion of multiple circle RNA loci by CRISPR‐Cas9 reveals Os06circ02797 as a putative sponge for OsMIR408 in rice

J Zhou, M Yuan, Y Zhao, Q Quan, D Yu… - Plant Biotechnology …, 2021 - Wiley Online Library
CRISPR‐Cas9 is an emerging genome editing tool for reverse genetics in plants. However,
its application for functional study of non‐coding RNAs in plants is still at its infancy. Despite …

Characterization and Cloning of Grape Circular RNAs Identified the Cold Resistance-Related Vv-circATS1

Z Gao, J Li, M Luo, H Li, Q Chen, L Wang… - Plant …, 2019 - academic.oup.com
Circular RNAs (circRNAs) are widely distributed and play essential roles in a series of
developmental processes, although none have been identified or characterized in …

Identification, biogenesis, function, and mechanism of action of circular RNAs in plants

R Liu, Y Ma, T Guo, G Li - Plant communications, 2023 - cell.com
Circular RNAs (circRNAs) are a class of single-stranded, closed RNA molecules with unique
functions that are ubiquitously expressed in all eukaryotes. The biogenesis of circRNAs is …

Characterization and function of circular RNAs in plants

P Zhang, S Li, M Chen - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
CircRNAs are covalently closed-loop single-stranded RNA molecules ubiquitously
expressing in eukaryotes. As an important member of the endogenous ncRNA family …

Identification and functional characterization of tomato circRNAs derived from genes involved in fruit pigment accumulation

J Tan, Z Zhou, Y Niu, X Sun, Z Deng - Scientific Reports, 2017 - nature.com
CircRNAs, a class of widespread circular RNAs produced from precursor mRNA back-
splicing, have been implicated in regulation of gene expression in eukaryotes, but their …