Adequate 24-h BP control presently offers the most feasible intervention for reducing
glomerular BP transmission and improving suboptimal outcomes in CKD. Investigations …

688 Hypertension October 2017 clinical patterns of HIRD susceptibility schematically
illustrated in Figure 1 with respect to the BP threshold for HIRD and the slopes of the …

Preeclampsia is characterized by reduced placental perfusion with placental ischemia and
hypertension during pregnancy. Preeclamptic women also exhibit a heightened …

Preeclampsia is a major obstetric problem defined by new-onset hypertension and
proteinuria associated with compromised placental perfusion. Although activation of the …

The 5/6 nephrectomy rat remnant kidney model is commonly used to study chronic kidney
disease (CKD). This model requires the removal of one whole kidney and two-thirds of the …

Background Abnormal renal hemodynamic responses to salt‐loading are thought to
contribute to salt‐sensitive (SS) hypertension. However, this is based largely on studies in …

The relative contribution of self-perpetuating versus hemodynamic-induced fibrosis to the
progression of chronic kidney disease (CKD) after acute kidney injury (AKI) is unclear. In the …

Chronic ANG II infusion in rodents is widely used as an experimental model of hypertension,
yet very limited data are available describing the resulting blood pressure-renal blood flow …

New Findings What is the central question of this study? Does antagonism of V1b receptors
prevent the haemodynamic and renal sympathetic nerve responses that occur with …

Most patients with essential hypertension do not exhibit substantial renal damage. Renal
autoregulation by preventing glomerular transmission of systemic pressures has been …