Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and
neuropeptides. In this review, we examine the variability in the individual peptides produced …

This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

Dopamine neurons of the ventral tegmental area (VTA DA) respond to food and social
stimuli and contribute to both forms of motivation. However, it is unclear whether the same or …

As a key regulator of the unfolded protein response, the transcription factor XBP1 activates
genes in protein secretory pathways and is required for the development of certain secretory …

Pro-opiomelanocortin (POMC) is a prohormone that encodes multiple smaller peptide
hormones within its structure. These peptide hormones can be generated by cleavage of …

This paper presents the eleventh update of the human obesity gene map, which
incorporates published results up to the end of October 2004. Evidence from single‐gene …

Peptide neurotransmitters and peptide hormones, collectively known as neuropeptides, are
required for cell-cell communication in neurotransmission and for regulation of endocrine …

Activity-dependent secretion of BDNF is important in mediating synaptic plasticity, but how it
is achieved is unclear. Here we uncover a sorting motif receptor-mediated mechanism for …

Before transmitter-filled synaptic vesicles can fuse with the plasma membrane upon
stimulation they have to be primed to fusion competence. The regulation of this priming …

Reduced food intake brings about an adaptive decrease in energy expenditure that
contributes to the recidivism of obesity after weight loss. Insulin and leptin inhibit food intake …