Numerous disease-causing parasites must invade host cells in order to prosper.
Collectively, such pathogens are responsible for a staggering amount of human sickness …

Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, contains
cysteine, serine, threonine, aspartyl and metallo peptidases. The most abundant among …

The protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, is an
obligate intracellular protozoan pathogen. Overlapping mechanisms ensure successful …

The use of glycosylphosphatidylinositol (GPI) to anchor proteins to the cell surface is
widespread among eukaryotes. The GPI-anchor is covalently attached to the C-terminus of a …

Major surface protease (MSP or GP63) is the most abundant glycoprotein localized to the
plasma membrane of Leishmania promastigotes. MSP plays several important roles in the …

A decade of genome sequencing has transformed our understanding of how trypanosomatid
parasites have evolved and provided fresh impetus to explaining the origins of parasitism in …

Antimicrobial peptides (AMPs) are multifunctional components of the innate systems of both
insect and mammalian hosts of the pathogenic trypanosomatids Leishmania and …

Trypanosoma cruzi is the causal agent of Chagas' disease which affects millions of people
around the world mostly in Central and South America. T. cruzi expresses a wide variety of …

Infections caused by resistant microorganisms often fail to respond to conventional therapy,
resulting in prolonged illness, increased treatment costs and greater risk of death …

Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, and
Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, the agents of …