Diseases caused by Leishmania present a worldwide problem, and current therapeutic
approaches are unable to achieve a sterile cure. Leishmania is able to persist in host cells …

Invariant natural killer T (iNKT) cells are CD1d-restricted, lipid-reactive T cells that exhibit
preponderant immunomodulatory properties. The ultimate protective or deleterious functions …

The role of NKT cells in the resistance or susceptibility towards Leishmania infections
remains to be defined, since controversial data persist. The response of these cells seems to …

Background Miltefosine (MIL) is currently the only oral drug available to treat visceral
leishmaniasis but its use as first-line monotherapy has been compromised by an increasing …

NKT cells play an important role in autoimmune diseases, tumor surveillance, and infectious
diseases, providing in most cases protection against infection. NKT cells are reactive to …

Resistance to murine visceral leishmaniasis (VL) correlates with the development of an IFN‐
γ predominant immune response. Beta1, 4‐galactose terminal glycans are potent inducers …

The pathogenesis of cutaneous leishmaniasis (CL) caused by Leishmania (Viannia)
braziliensis is dictated mainly by the immune-mediated-tissue inflammation developed. The …

The development of inflammatory granulomas around infected Kupffer cells is necessary for
hepatic parasite clearance during visceral leishmaniasis. Invariant NKT (iNKT) cells are …

Hampering‐surface presentation of immunogenic peptides by class I/II MHCs is a key
strategy opted by several intracellular protozoan pathogens including Leishmania to escape …

During Leishmania donovani (LD) infection Interleukin (IL)-10 favors parasite replication and
plays a central role as a target for immune-based therapy. Glycogen synthase kinase 3 …