Pluripotent stem cells in disease modelling and drug discovery
Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …
molecular mechanisms underlying diseases and the development of therapies for treating …
Human-induced pluripotent stem cells: potential for neurodegenerative diseases
CA Ross, SS Akimov - Human molecular genetics, 2014 - academic.oup.com
The cell biology of human neurodegenerative diseases has been difficult to study till
recently. The development of human induced pluripotent stem cell (iPSC) models has …
recently. The development of human induced pluripotent stem cell (iPSC) models has …
From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium
S Reichman, A Terray, A Slembrouck… - Proceedings of the …, 2014 - National Acad Sciences
Progress in retinal-cell therapy derived from human pluripotent stem cells currently faces
technical challenges that require the development of easy and standardized protocols. Here …
technical challenges that require the development of easy and standardized protocols. Here …
[HTML][HTML] Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease
S Chakraborty, BYL Cheng, DL Edwards, JC Gonzalez… - Immunity, 2025 - cell.com
While most respiratory viral infections resolve with little harm to the host, severe symptoms
arise when infection triggers an aberrant inflammatory response that damages lung tissue …
arise when infection triggers an aberrant inflammatory response that damages lung tissue …
A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs
The Notch pathway is a conserved cell-cell communication pathway that controls cell fate
decisions. Here we sought to determine how Notch pathway activation inhibits the …
decisions. Here we sought to determine how Notch pathway activation inhibits the …
Multiscale modeling uncovers 7q11. 23 copy number variation–dependent changes in ribosomal biogenesis and neuronal maturation and excitability
M Mihailovich, PL Germain, R Shyti, D Pozzi… - The Journal of clinical …, 2024 - jci.org
Copy number variation (CNV) at 7q11. 23 causes Williams-Beuren syndrome (WBS) and 7q
microduplication syndrome (7Dup), neurodevelopmental disorders (NDDs) featuring …
microduplication syndrome (7Dup), neurodevelopmental disorders (NDDs) featuring …
Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation
L D'Aiuto, Y Zhi, D Kumar Das, MR Wilcox… - …, 2014 - Taylor & Francis
Induced pluripotent stem cell (iPSC)-based technologies offer an unprecedented opportunity
to perform high-throughput screening of novel drugs for neurological and …
to perform high-throughput screening of novel drugs for neurological and …
Huntington disease as a neurodevelopmental disorder and early signs of the disease in stem cells
K Wiatr, WJ Szlachcic, M Trzeciak, M Figlerowicz… - Molecular …, 2018 - Springer
Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion
mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an …
mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an …
Transcription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspective
LM Valor - Molecular neurobiology, 2015 - Springer
Transcriptional dysregulation in Huntington's disease (HD) is an early event that shapes the
brain transcriptome by both the depletion and ectopic activation of gene products that …
brain transcriptome by both the depletion and ectopic activation of gene products that …
Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer
Comprehensive genomic analyses of small cell lung cancer (SCLC) have revealed frequent
mutually exclusive genomic amplification of MYC family members. Hence, it has been long …
mutually exclusive genomic amplification of MYC family members. Hence, it has been long …